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ea0058oc4.7 | Oral Communications 4 | BSPED2018

Clinical outcomes of focal congenital hyperinsulinism – a UK perspective

Dastamani Antonia , Yau Daphne , Gilbert Clare , Morgan Kate , O'Shea Elaine , Pimlott Helen , DeCoppi Paolo , Craigie Ross , Flanagan Sarah , Houghton Jayne , Senniappan Senthil , Didi Mohammed , Banerjee Indi , Shah Pratik

Background: The focal type of Congenital Hyperinsulinism (CHI) is characterized by a cluster of abnormal insulin over-secreting β-cells within a restricted area of the pancreas. Early identification and intervention of the focal lesion is critical in CHI management, preventing both acute and chronic complications.Objective: The purpose of this study is to review outcomes of treatment response in focal CHI.Design: Retr...

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ea0058oc5.9 | Oral Communications 5 | BSPED2018

Diazoxide-induced pulmonary hypertension: UK multicentre retrospective study on the risk factors, monitoring approach andmanagement recommendations

Ching Chen Suet , Dastamani Antonia , Pintus Donatella , Yau Daphne , Aftab Sommayya , Bath Louise , Swinburne Craig , Hunter Lindsey , Giardini Alessandro , Christov Georgi , Senniapan Senthil , Banerjee Indraneel , Shaikh Guftar , Shah Pratik

Objectives: Diazoxide is first line treatment for hypoglycaemia due to hyperinsulinaemic hypoglycaemia (HH). Although sporadic cases of pulmonary hypertension (PH) have been reported, no HH cohort has been systematically characterised to understand severity and risk factors for diazoxide-induced PH.Methods: To investigate the onset, progress and associated factors in PH, patients with HH who developed diazoxide-induced PH in 4 regional centres were retro...

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Endocrine Abstracts

Clinical outcomes of focal congenital hyperinsulinism – a UK perspective

Diazoxide-induced pulmonary hypertension: UK multicentre retrospective study on the risk factors, monitoring approach andmanagement recommendations

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